Mechanisms of Autoimmunity in Animal Models and Humans

Mechanisms of Autoimmunity in Animal Models and Humans Norzawani Binti Buang Genetic and cellular mechanisms of autoimmunity in animal models and humans

Revenge and Emotions Essay -- Literary Analysis, Shakespeare

In the world today, many people face family problems every single day, but there are few people who face adversities as tough as those in William Shakespeare’s plays. Coping with family problems can cause a person to do vile things to themselves as well as to others. Shakespeare’s famous play revolves around revenge, which is the desire to do harm in return for a wrong. His play shows how the loss of loved ones can affect people. He builds up the idea that people do harmful things through anger rather than reasoning. In the play Hamlet, the characters face emotions that lead to revenge because they are unable to cope with the death of love ones. Hamlet’s Uncle Claudius kills his father, but he has no knowledge of this. The ghost says, â€Å"I am thy father’s spirit, doomed for a certain term to walk to the night, and for the day confined to fast in fires, till the foul crimes done in my days of nature are burnt and purged away† (I.v.9-33). The ghost tells Hamlet that he is his father and that a foul crime has been committed. He also tells him that the crime is forgotten. Hamlet finds out that his uncle kills his father by pouring poison in his ear while he is sleeping. Ghost says, â€Å"List, list, O, list! If thou didst ever thy dear father love —† (I.v.21-23). At this point, the ghost is saying to Hamlet if he has any love for his father he will avenge his death. The ghost states, â€Å"Revenge his foul and most unnatural murder† (I.v.25). Hamlet’s father is telling him to get revenge for his death. Hamlet ‘s initial reaction is to avenge his father, a reaction that is brought on by a sudden shock of the ghost’s confession.To prove that Hamlet has love for his father he is going to avenge his father’s death. â€Å"Haste me to know’t, that... ...and wounds the king. Hamlet finds out that the king poisoned the drink that killed his mother. Hamlet is full of rage and runs his uncle through with the poisoned sword. Hamlet states, â€Å"Here, thou incestuous, murd’rous damned Dane, drink off this potion. Is thy union here? Follow my mother† (V.ii.304-306). Hamlet makes the king drink the same drink that kills his mother. Hamlet has fulfilled the ghost’s wishes. The theme of revenge reaches its conclusion when Hamlet kills Claudius. Revenge is the core theme in Shakespeare’s Hamlet. Death of loved ones cause the characters to act blindly through anger and emotion which cause them to carry out revenge. Hamlet has opportunities to kill Claudius, but he waits until the time is right to kill him. Hamlet, and the Laertes both accomplishes their task. Their obsession and need for revenge lead them to their downfalls.

The Growth Stage

The growth stage brings many challenges to blended value businesses, and one of the most significant concerning mission preservation involves changes in leadership during scaling, especially to the role of the founder. It is common in early-stage businesses for the founder to guide all aspects of the organization. When companies begin to grow, however, things start to change. From this moment onward, the involvement of the founder with the company must evolve as much as the firm itself does. At this point, formal governance systems and processes must be created to take the place of the informal ones employed during the start-up phase. The transfer of responsibility from the charismatic individual, the founder, to the governing board is one hallmark of a more substantial shift toward a more systemized, collaborative approach that needs to take place in all businesses as they grow (Clark, Emerson & Thornley, 2014). For social entrepreneurships, it can signal a dangerous moment for the social mission. Often the founder's leadership—his or her passion and vision—is what establishes the clear connection between the business and mission in the first place. As the leadership shifts from founder to governing board, new ways need to be found to embed mission in the systems that will provide direction for the business from this point on. Shifting leadership from founder to board can be a challenge for many types of organizations, but it may present a particular obstacle for social entrepreneurships. The figure of the founder looms large in the social impact world encouraged by a high number of prizes and programs aimed at individual entrepreneurs. Partly as a result of such well-meaning support efforts, some founders have risen to personal prominence alongside their blended value companies, becoming public faces for their businesses, ambassadors for their brand with high media, and field level visibility. At the growth stage, such over-emphasis on founders can create the conditions under which so-called founder's syndrome can arise.

The Rocking

The Rocking Book Summary The Rocking-Horse Winner describes a young boy’s search for luck and love in a world with no love. Paul has a gift of picking the winning horse in horse races. His mother, Hester, in contrary, has no luck and even though she is outwardly successful, she is troubled by a feeling of failure.Advertising We will write a custom essay sample on The Rocking-Horse Winner specifically for you for only $16.05 $11/page Learn More The family’s expenditure exceeds its income and creates unspoken tension and this affects the relationships in the family. Paul and his two sisters recognize this tension and Paul even alleges that he can hear the house whispering, â€Å"There must be more money† (Lawrence, 1926). Paul informs his uncle (Oscar) and Bassett, the gardener, about his luck on betting in horses: he has been betting using his pocket money and has won and accumulated some money. Both men place huge bets on the horse Paul identifies t o be a potential winner. After their win, Paul and Bassett give Paul’s mother a very expensive gift, but this makes her spend more money, this upsets Paul and he works harder to be lucky. As a Derby race nears, Paul strives to know the name of the winning horse. He does this by riding his rocking horse so that he can get to a state in which he can be sure about the winning horse. He remains sick on the day of the Derby but Bassett places bets on the horse that was identified by Paul, and even places a bet for Paul. The horse wins and Paul wins eighty thousand pounds, however, he dies at night. Analysis The Rocking-Horse Winner presents a society in search of love and luck and this is evident from a number of characters. The main characters in the short story, Paul and Hester, are in search of love. Paul’s mother, Hester, entered marriage with a handsome man because of love, but the love died. Even though she has three children out of the marriage, she could not love th em, and does not even love herself for she is troubled by a feeling of failure. The closest she ever comes to finding love is through her son, Paul, but she rejects him too. Indeed, her lack of love for her children is shown when the author writes, â€Å"only she herself knew that at the centre of her heart was a hard little place that could not feel love, no, not for anybody† (Lawrence, 1926). While everyone thinks of her as a great parent, only she knows that her heart is hard and cannot love, not even her children who need it very much. To her, success and happiness means getting more money. Hester’s desire for material wealth surpasses that of other important things such as love and self-knowledge. Her desire for money is insatiable, instead, they lead to disastrous results when she confuses money with love. In her pursuit of more money, Hester loses some basic family values.Advertising Looking for essay on american literature? Let's see if we can help you! Get your first paper with 15% OFF Learn More Her main aim is to bring up her children in a flamboyant lifestyle, as a result, her relationship with her children and husband dies. Whenever she gets money, she overspends it. Although the family lives in a â€Å"pleasant house† complete with servants and a nurse, they take them as show off objects. Hester’s uncontrollable spending creates tensions inside the household and this is personified by the whispering sounds that seem to come out the house and say â€Å"there must be more money† (Lawrence, 1926). Paul’s talk with his mother about luck makes him believe that her mother’s love can only be won with money and luck. She makes a strong connection with luck and money. When Paul asks her whether luck was money, she replies, â€Å"Its what causes you to have money† (Lawrence, 1926). From this talk, Paul concludes that his luck would make her happy, and this would translate to lo ve. In contrary, she becomes greedier and is more concerned about money than loving her son (Snodgrass, pp. 196). Paul’s ability to identify the winning horse pulls Oscar and Bassett into the betting business. Paul would get onto a rocking boat and rock continuously, like he was part of the race, until he got into a state in which he was sure of the winning horse. At the final race, Paul drives himself harder and harder to identify the winning horse. His mother’s insatiability and whispering house drives him to try more and more as he knew that he would achieve two important things if he identified the winning horse: make his mother happy, and win her love. Paul’s desperate actions are an attempt to win love from his hard-hearted mother. These efforts leave him sick and weak. After Bassett tells him that he had won eighty thousand pounds from the derby race, he tells his mother, â€Å"†¦did I ever tell you? I am lucky!† to which the mother replies, à ¢â‚¬Å"No, you never did† (Lawrence, 1926), this proves that Hester never loved her children, especially Paul. Paul dies that night after failing to win his mother’s love. Lawrence, David Herbert Richards. The Rocking-Horse Winner. In The Norton Introduction to Literature. Alison Booth and Kelly J. Mays, eds. Portable 10th ed. New York: Norton, 2011. Print.Advertising We will write a custom essay sample on The Rocking-Horse Winner specifically for you for only $16.05 $11/page Learn More Snodgrass, William de Witt. A Rocking-Horse: The Symbol, the Pattern, the Way to Live. The Hudson Review, Vol. 11, No. 2, 1958, pp. 191-200

The Future of Human Computer Interface and Interactions

The Future of Human Computer Interface and Interactions Introduction The society today has completely changed due to technology. Technology is changing at a very rapid rate and with the changes come the need to adapt to them. Computer has changed the way human being does his activities (Beaureau 2008, p.36). Unlike before when most of the activities were done manually, computer has enabled automation of most of activities, especially in large companies.Advertising We will write a custom essay sample on The Future of Human Computer Interface and Interactions specifically for you for only $16.05 $11/page Learn More It is now possible for a manager to monitor activities taking place in a different company’s branch from where he or she is by use of computerized gadgets. Management and other duties have been redefined by introduction of the modern day gadgets that are computer controlled. The Future of Human Computer Interface and Interactions Human Computer Interface refers to the interactivity between compute r and people (Sutherland, Robertson and John 2009, p.49). Unlike other gadgets that do not communicate with the user, computer is the only tool that will have a direct communication with the user. This interactivity is made possible by both the software and the hardware. The user passes the communication by use hardware like mouse and keyboard and receives the communication through characters displayed on monitor, or through sound. However, this method of communication is only reliable to people who are not handicapped. People without hands and those that are mentally handicapped may not be in a position to operate the traditional computers properly (Rodgers and Streluk 2002, p.98). However, this may be changing very soon. Dr. Eric Leuthardt and a group of other scientist have developed a new computer interface that would accommodate the physically handicapped. This interface allows one to control the computer using the brain. The computer is programmed to read the mind and respond to the demands of that mind. By using the power of their thought, these physically handicapped individuals are able to control the cursor to issue commands to the computer. This interface will also benefit individuals with spinal code injuries or paralysis This invention is so sophisticated as in makes it possible for anyone to use this gadget regardless of the physical challenges that one may be having. Moreover, it comes with speed as the commands will be issued as soon as they come to the mind.Advertising Looking for essay on computer science? Let's see if we can help you! Get your first paper with 15% OFF Learn More When iPad was launched, everyone was asking what the next invention will be. A group of Australian scientist has come with a new invention that is very similar to that of iPad. It has the ability to read anything placed on it. This makes it very appropriate in places that require high level of security like in the airports or the five star hot els. It can also be of good use in places like supermarkets in the billing section. The future of human computer interface and interactivity is already here. Life is becoming easier with every technological invention. This has a positive impact both in the short and long run, especially in the field of entertainment and digital divide. Human being will also be able to delegate much of his duties to computers. A keener look into this phenomenon will reveal that in as much as these inventions are necessary and that they have positive impact on mankind, it is also true that they come at a cost. The effect of these sophisticated machines on the environment is adverse, especially when poorly disposed (Abbot 2001, p.79). These inventions will also impact negatively on culture, as life becomes what one wants, regardless of age. It is therefore necessary to take care as we embrace this technology. List of References Abbot, C 2001, ICT: Changing Education, New York, Routledge. Beaureau, B 20 08, Information and Communication Technology: The Industrial Revolution That Wasn’t, New York, Lulu. Rodgers, A, and Streluk, A 2002, ICT Key Stage 1, London, Nelson Thornes Ltd. Sutherland, R, Robertson, S and John, P 2009, Improving Classroom Learning with ICT, New York, Routledge.Advertising We will write a custom essay sample on The Future of Human Computer Interface and Interactions specifically for you for only $16.05 $11/page Learn More

The commercial invoice; the pro forma invoice Assignment

The commercial invoice; the pro forma invoice - Assignment Example Question 2 The amount of risk that a business will bear will depend on whether the business is the importer or the exporter, as well as the particular incoterms that are involved on a particular transaction. For instance, if the business is an importer, the business will incur the least risk if the incoterm being used is CIF, because this will have the least risk (William, 2009). This is because the seller (exporter) will have to take care of the goods on their way not only to the destination port but all the way to the inland destination of the buyer. This includes buying the insurance for the goods as they are on transit. As a result, this means two important things to the buyer, who is the importer. First, is that there is no risk of the goods on transit that the importer will have to bear incase the risk materializes. Second is that even if the risk was to materialize, the importer would be protected because the insurance will pay off the losses. The importance of Cost, Insurance and Freight (named port of destination) is that incase the goods are lost or damaged and the seller was not in a position to compensate the buyer, the buyer doesn’t have to incur the loss because the insurance will pay for the goods. ... The fact that the process by which the US government uses to create money and value for the same money is faulty and needs to be changed is not debatable. However, as Maxwell (2009) says, it can only be hoped that the new technology that is eliminating the issuance of printed money will solve part of this problem. However, this is a problem that will need to be solved and a better mechanism be put in place to avoid the problem that fiat currency is causing. This as McGregory (2009) says, is going to be one of the main things that will have to be solved in the twenty-first millennium for the world economy to succeed. Question 4 Part i FOB – Free on Board to a named port of shipment This incoterm makes sure that the risk of the goods is shared between the two sides of the deal. The buyer assumes the risk after the goods have been loaded for shipping, while the seller assumes the risk of the goods only until the goods have been loaded for shipping. Part ii CIF – Cost, Insu rance and Freight to a named port of destination This incoterm puts all obligation, both transport and insurance of the goods in transit to the seller and makes sure that the buyer is fully protected from any risk or obligation. Part iii CIF – Cost, Insurance and Freight to a named port of destination Same as above, the exporter assumes all risks and costs for shipping the goods. Part IV EXW – Ex Works to a named place of delivery. This incoterm minimizes the obligation of the exporter so that the exporter only has insurance and freight costs only up to the point where the goods are loaded at the port of export. The buyer has to know how to get the goods from the seller’s premises and decide on whether they want to

Yank in The Hairy Ape Essay Example | Topics and Well Written Essays - 500 words

Yank in The Hairy Ape - Essay Example He does not reveal much about his roots, but it is evident that his childhood was painful. In the pauses between his parents’ incessant fighting during which furniture got broken, he was made to attend church every Sunday morning, only to be forced to run away after his mother’s death, when he could not handle any more of his father’s beatings. His troublesome beginnings have taught him that he will be forced to fend for himself in this cruel world. However, since man is a social being and thrives on the interaction with other members of the society, he needs to belong. Yank equates this highly relevant notion of belonging with power and importance. When he believes he belongs to something, he gains strength and feels almost invincible, but when he is rejected by a group, he feels terribly weak. He also associates this sense of belonging with the usefulness and functionality of an individual. For example, the firemen belong to the ship due to the fact that they a re essentially responsible for the proper functioning of the ship. Despite the fact that he believes himself to be essential for this, the fact of the matter is that industrialization has reduced the human worker into a machine.